Q Therapeutics Announces Joint Venture With REPROCELL
Q Therapeutics and REPROCELL announced the formation of MAGiQ Therapeutics, Inc., a Japanese joint venture company. MAGiQ will develop iPSC-derived, glial-restricted progenitor cells (GRPs), in collaboration with Q Therapeutics and REPROCELL, to treat demyelinating and degenerative diseases of the CNS.
“MAGiQ Therapeutics aims to bring this promising cell therapy product to market first in a favorable regulatory environment and to begin treating patients as soon as possible,” said Koji Kuchiishi, MAGiQ’s founding CEO and a board member of REPROCELL.
Under the leadership of Kuchiishi and Chief Scientific Officer Mahendra Rao MD, PhD, MAGiQ will first target the demyelinating disease transverse myelitis and the degenerative disease amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease). The iPSC-derived GRP cell (iGRP) product will be tested in proof-of-concept human trials, sponsored by REPROCELL, under the accelerated approval pathway permitted by Japan’s PMDA. This unique regulatory process, designed to move cell and gene therapies to human use more rapidly than in most countries, will enable clinical data and conditional product approval for application to regulatory filings worldwide.
MAGiQ is a 50:50 joint venture, in which Q Therapeutics will contribute its patented technology to derive and manufacture glial-restricted progenitor (GRP) cells from any tissue source, including iPSC. REPROCELL will support manufacturing process development of iGRPs through to completion of proof-of-concept clinical trials in addition to providing integration-free, virus-free and clinically relevant human iPSC lines using proprietary RNA reprogramming technology. The clinical data will equip both MAGiQ and Q Therapeutics to bring the iGRP product to other indications and markets.
“I am pleased to advance Q’s relationship with REPROCELL. Our joint venture will extend the product pipeline, build on our foundational experience in developing glial cell therapies, and demonstrate the clinical benefits of glial cell technology in multiple clinical trials,” said Steven Borst, CEO of Q Therapeutics. “I look forward to serving on the MAGiQ Therapeutics Board of Directors, along with Dr. Chikafumi Yokoyama, CEO of REPROCELL.”
“REPROCELL is committed to expanding its business from tools and services to cell-based therapies. Our joint venture with Q Therapeutics is a next step in our business development strategy and builds on our previous collaborations in the cell therapy arena. Our regulatory expertise will allow MAGiQ to move this clinical effort quickly toward conditional approval in Japan,” said Dr. Yokoyama, “The PMDA and the Japanese government have provided a clear path to accelerate development of regenerative medicine therapies.”