Applied Therapeutics Initiates Phase 1 Trial for AT-001 In Diabetic Complications
Applied Therapeutics announced initiation of a Phase 1 clinical trial for AT-001, an oral small molecule in development for diabetic complications.
The Phase 1 clinical trial is a first-in-human, randomized, placebo-controlled, dose escalation study to assess the safety and tolerability, pharmacokinetics and pharmacodynamics of AT-001 in patients with Type 2 Diabetes. The study will also evaluate a specific biomarker to assess patient response.
“Initiation of this study represents a significant milestone for Applied Therapeutics, as we advance our first compound, AT-001, into the clinic,” said Shoshana Shendelman, Ph.D., Founder, Chairman and CEO of Applied Therapeutics. “We are excited to bring our therapy one step closer to patients.”
“The rapid movement from translational research to the clinic is a model of academic research collaboration and focused biotech development. We are pleased to see our work making its way to patients quickly, and we hope that AT-001 will transform the treatment of diabetic complications as a safe and efficacious therapy,” stated Donald Landry, M.D., Ph.D., Chairman of the Department of Medicine at Columbia Medical Center and Chairman of the Applied Therapeutics Scientific Advisory Board.