Bristol-Myers Squibb (BMS) and Calithera Biosciences expanded their collaboration to evaluate BMS’s Opdivo in combination with Calithera’s CB-839 in patients with non-small cell lung cancer (NSCLC) and melanoma. CB-839 is an investigational orally administered glutaminase inhibitor currently in Phase 1/2 clinical studies.
Preclinical data suggest that CB-839, which is designed to target a pathway to starve tumor cells of the key nutrient glutamine, may enhance the effects of checkpoint inhibitors and may also reverse tumor resistance to checkpoint inhibitors by altering the immune-suppressive microenvironment and promoting an anti-tumor immune response. Opdivo is designed to overcome immune suppression.
BMS senior VP, Head of Oncology Development, Fouad Namouni said that they are pleased to expand their collaboration with Calithera into NSCLC and melanoma, building upon their existing clinical study evaluating Opdivo and CB-839 in clear cell renal cell carcinoma.
Calithera Biosciences CEO, Susan Molineaux said that the expansion of this clinical collaboration with Bristol-Myers Squibb into NSCLC and melanoma is an important addition to our immunotherapy clinical strategy for CB-839. This represents one of several strategies to develop CB-839, a glutaminase inhibitor, in combination with approved therapies with the hope of improving the treatment of patients with solid tumors.